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Chemical structure of MRTX1133

GC62699

MRTX1133

Also known as 4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol

MRTX1133 is an exceptionally potent and selective KRASG12D inhibitor with high affinity (<2nM)

ChemicalCAS2621928-55-8MW600.63FormulaC33H31F3N6O2
CAS number
2621928-55-8
Molecular weight
600.63
Formula
C33H31F3N6O2
Solubility
DMSO ： 50 mg/mL
InChIKey
SCLLZBIBSFTLIN-IFMUVJFISA-N
Catalogue number
GC62699
Brand
GLPBIO
Computed properties PubChem CID 156124857 · XLogP 5.2 · TPSA 86.6 Ų · H-bond donors 2
XLogP
5.2
TPSA
86.6 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
44

SMILES C#CC1=C(C=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5CC6CCC(C5)N6)OC[C@@]78CCCN7C[C@@H](C8)F)O)F

Computed descriptors from PubChem (CID 156124857), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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