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Chemical structure of MRTX849

GC38400

MRTX849

Also known as 2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile

MRTX849 (Adagrasib) is a highly potent and selective covalent inhibitor of KRASG12C, with an IC50 value of 5nM

ChemicalCAS2326521-71-3MW604.12FormulaC32H35ClFN7O2
CAS number
2326521-71-3
Molecular weight
604.12
Formula
C32H35ClFN7O2
Solubility
DMSO： 25 mg/mL (41·38 mM)
InChIKey
PEMUGDMSUDYLHU-ZEQRLZLVSA-N
Catalogue number
GC38400
Brand
GLPBIO
Computed properties PubChem CID 138611145 · XLogP 5 · TPSA 88.8 Ų · H-bond donors 0
XLogP
5
TPSA
88.8 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
43

SMILES CN1CCC[C@H]1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN([C@H](C6)CC#N)C(=O)C(=C)F

Computed descriptors from PubChem (CID 138611145), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.