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Chemical structure of PROTAC IDO1 Degrader-1

GC62689

PROTAC IDO1 Degrader-1

Also known as N'-(3-bromo-4-fluorophenyl)-4-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide

PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2·84 μM)

ChemicalCAS2488851-89-2MW966.8FormulaC40H53BrFN9O13
CAS number
2488851-89-2
Molecular weight
966.8
Formula
C40H53BrFN9O13
Solubility
DMSO ： 100 mg/mL (103·43 mM; Need ultrasonic)
InChIKey
BVQZWOPTIZSOAW-UHFFFAOYSA-N
Catalogue number
GC62689
Brand
GLPBIO
Computed properties PubChem CID 162640820 · XLogP 1.3 · TPSA 268 Ų · H-bond donors 6
XLogP
1.3
TPSA
268 Ų
H-bond donors
6
H-bond acceptors
20
Rotatable bonds
33
Heavy atoms
64

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCOCCOCCNCCNC4=NON=C4C(=NC5=CC(=C(C=C5)F)Br)NO

Computed descriptors from PubChem (CID 162640820), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.