Loading...
Chemical structure of PROTAC CDK2/9 Degrader-1

GC62666

PROTAC CDK2/9 Degrader-1

Also known as N-[4-[[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethylamino]-4-oxobutanoyl]piperazin-1-yl]methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM)· PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0·12 ?M) by effectively blocking the cell cycle in S and G2/M phases· PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand

ChemicalCAS2408641-24-5MW815.84FormulaC40H41N13O7
CAS number
2408641-24-5
Molecular weight
815.84
Formula
C40H41N13O7
Solubility
DMSO ： 130 mg/mL (159·34 mM; Need ultrasonic)
InChIKey
BRYMZSSAIDEFEM-UHFFFAOYSA-N
Catalogue number
GC62666
Brand
GLPBIO
Computed properties PubChem CID 145925673 · XLogP 1.3 · TPSA 260 Ų · H-bond donors 7
XLogP
1.3
TPSA
260 Ų
H-bond donors
7
H-bond acceptors
13
Rotatable bonds
14
Heavy atoms
60

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCNC(=O)CCC(=O)N4CCN(CC4)CC5=CC=C(C=C5)NC(=O)C6=C(C=NN6)NC7=NC=NC8=C7C=CN8

Computed descriptors from PubChem (CID 145925673), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.