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Chemical structure of G140

GC62664

G140

Also known as 1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14·0?nM and 442?nM for h-cGAS and m-cGAS, respectively

ChemicalCAS2369751-07-3MW379.24FormulaC17H16Cl2N4O2
CAS number
2369751-07-3
Molecular weight
379.24
Formula
C17H16Cl2N4O2
Solubility
DMSO ： 250 mg/mL (659·21 mM; Need ultrasonic)
InChIKey
NVPFAXHXXODQRO-UHFFFAOYSA-N
Catalogue number
GC62664
Brand
GLPBIO
Computed properties PubChem CID 139388865 · XLogP 2 · TPSA 74.2 Ų · H-bond donors 2
XLogP
2
TPSA
74.2 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
25

SMILES CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl

Computed descriptors from PubChem (CID 139388865), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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