GC62632
JBJ-04-125-02
Also known as (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-[3-oxo-5-(4-piperazin-1-ylphenyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0·26 nM for EGFRL858R/T790M· JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling· JBJ-04-125-02 has anti-tumor activities
ChemicalCAS2060610-53-7MW543.61FormulaC29H26FN5O3S
- CAS number
- 2060610-53-7
- Molecular weight
- 543.61
- Formula
- C29H26FN5O3S
- InChIKey
- VHQVOTINPRYDAO-AREMUKBSSA-N
- Catalogue number
- GC62632
- Brand
- GLPBIO
Computed properties PubChem CID 124173751 · XLogP 3.8 · TPSA 126 Ų · H-bond donors 3
- XLogP
- 3.8
- TPSA
- 126 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Rotatable bonds
- 6
- Heavy atoms
- 39
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CC4=C(CN(C4=O)[C@H](C5=C(C=CC(=C5)F)O)C(=O)NC6=NC=CS6)C=C3
Computed descriptors from PubChem (CID 124173751), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il