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Chemical structure of M8891

GC62619

M8891

Also known as (3S)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide

M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4·33 nM

ChemicalCAS1464842-09-8MW385.36FormulaC20H17F2N3O3
CAS number
1464842-09-8
Molecular weight
385.36
Formula
C20H17F2N3O3
Solubility
DMSO ： 90 mg/mL (233·55 mM; Need ultrasonic)
InChIKey
WVGGJQVCOTYFPV-FQEVSTJZSA-N
Catalogue number
GC62619
Brand
GLPBIO
Computed properties PubChem CID 89855776 · XLogP 2.5 · TPSA 85.4 Ų · H-bond donors 3
XLogP
2.5
TPSA
85.4 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
28

SMILES C1CN(C(=O)[C@]1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4

Computed descriptors from PubChem (CID 89855776), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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