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Chemical structure of M8-B (hydrochloride)

GC18296

M8-B (hydrochloride)

Also known as N-(2-aminoethyl)-N-[(3-methoxy-4-phenylmethoxyphenyl)methyl]thiophene-2-carboxamide;hydrochloride

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7·8, 26·9, and 64·3 nM, respectively)

ChemicalCAS883976-12-3MW433FormulaC22H24N2O3S·HCl
CAS number
883976-12-3
Molecular weight
433
Formula
C22H24N2O3S·HCl
Solubility
DMF： 10 mg/ml,DMSO： 15 mg/ml,DMSO：PBS (pH 7·2) (1：1)： 0·5 mg/ml
InChIKey
FMQJBHACRTZLME-UHFFFAOYSA-N
Catalogue number
GC18296
Brand
GLPBIO
Computed properties PubChem CID 69316632 · TPSA 93 Ų · H-bond donors 2 · H-bond acceptors 5
TPSA
93 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
29

SMILES COC1=C(C=CC(=C1)CN(CCN)C(=O)C2=CC=CS2)OCC3=CC=CC=C3.Cl

Computed descriptors from PubChem (CID 69316632), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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