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Chemical structure of TD-165

GC62600

TD-165

Also known as (2S,4R)-1-[(2S)-2-[11-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]undecanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

TD-165 is a PROTAC-based cereblon (CRBN) degrader· TD-165 comprises a?cereblon (CRBN)?ligand binding group, a linker and an?von Hippel-Landau (VHL)?binding group

ChemicalCAS2305936-56-3MW870.07FormulaC46H59N7O8S
CAS number
2305936-56-3
Molecular weight
870.07
Formula
C46H59N7O8S
Solubility
DMSO : 50 mg/mL (57·47 mM; Need ultrasonic)
InChIKey
KSXVXTSIDVRZBR-IINAPWRYSA-N
Catalogue number
GC62600
Brand
GLPBIO
Computed properties PubChem CID 138574052 · XLogP 6.5 · TPSA 235 Ų · H-bond donors 5
XLogP
6.5
TPSA
235 Ų
H-bond donors
5
H-bond acceptors
11
Rotatable bonds
20
Heavy atoms
62

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)O

Computed descriptors from PubChem (CID 138574052), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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