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Chemical structure of RAS/RAS-RAF-IN-1

GC62504

RAS/RAS-RAF-IN-1

Also known as (3S)-N-[(2S)-1-[[(8S,14S)-22-(2-cyanopropan-2-yl)-4-hydroxy-18,18-dimethyl-9,15-dioxo-16-oxa-10,20,28-triazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),2,4,6(29),21,23(27),24-heptaen-8-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methyl-1-prop-2-enoylpyrrolidine-3-carboxamide

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor· RAS/RAS-RAF-IN-1 has a KD of 5·0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity· RAS/RAS-RAF-IN-1 has antitumor activity

ChemicalCAS2447039-81-6MW807.98FormulaC45H57N7O7
CAS number
2447039-81-6
Molecular weight
807.98
Formula
C45H57N7O7
InChIKey
RCXSKUOUWMZVFF-NXCZKTMTSA-N
Catalogue number
GC62504
Brand
GLPBIO
Computed properties PubChem CID 162642485 · XLogP 5.2 · TPSA 177 Ų · H-bond donors 3
XLogP
5.2
TPSA
177 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
59

SMILES CC(C)[C@@H](C(=O)N[C@H]1CC2=CC(=CC(=C2)O)C3=CC4=C(C=C3)C(=CN4CC(COC(=O)[C@@H]5CCCN(C1=O)N5)(C)C)C(C)(C)C#N)N(C)C(=O)[C@H]6CCN(C6)C(=O)C=C

Computed descriptors from PubChem (CID 162642485), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.