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Chemical structure of RAS inhibitor Abd-7

GC62421

RAS inhibitor Abd-7

Also known as 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-N-[4-[(dimethylamino)methyl]phenyl]-2-methoxypyridin-3-amine

RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor· RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling· RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V

ChemicalCAS2351843-48-4MW391.46FormulaC23H25N3O3
CAS number
2351843-48-4
Molecular weight
391.46
Formula
C23H25N3O3
Solubility
DMSO ： 125 mg/mL (319·32 mM; Need ultrasonic)|Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
MJHHFDJNRRCUOB-UHFFFAOYSA-N
Catalogue number
GC62421
Brand
GLPBIO
Computed properties PubChem CID 134812710 · XLogP 3.9 · TPSA 55.9 Ų · H-bond donors 1
XLogP
3.9
TPSA
55.9 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
29

SMILES CN(C)CC1=CC=C(C=C1)NC2=C(N=C(C=C2)C3=C4C(=CC=C3)OCCO4)OC

Computed descriptors from PubChem (CID 134812710), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
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