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Chemical structure of HS271

GC62429

HS271

Also known as N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7·2 μM

ChemicalCAS2410393-15-4MW435.44FormulaC21H24F3N5O2
CAS number
2410393-15-4
Molecular weight
435.44
Formula
C21H24F3N5O2
Solubility
DMSO ： 100 mg/mL (229·65 mM; Need ultrasonic)
InChIKey
QAOWCAZEVIIQTF-UHFFFAOYSA-N
Catalogue number
GC62429
Brand
GLPBIO
Computed properties PubChem CID 146386401 · XLogP 2.8 · TPSA 83.3 Ų · H-bond donors 2
XLogP
2.8
TPSA
83.3 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
31

SMILES CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)CCN(C)C)O

Computed descriptors from PubChem (CID 146386401), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.