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Chemical structure of HS666 hydrochloride

GB40234

HS666 hydrochloride

Also known as 3-[2-[cyclopropylmethyl(2-phenylethyl)amino]ethyl]phenol;hydrochloride

HS666 is a selective κ opioid receptor partial agonist (Ki value of 5·9 nM) which activates central κ receptors to produce potent antinociception· Moreover, HS666 displays pharmacological characteristics of a κ receptor analgesic with reduced liability for aversive effects correlating with its low efficacy in the β-arrestin2 signalling pathway·Keywords: HS666 hydrochloride | supplier | Kappa-opioid partial agonist | HS 666 hydrochloride | HS-666 hydrochloride | CAS [1409931-99-2] | [1409931-91-4] | Opioids | OPR-κ | Partial agonist | Receptors | Antinociception

ChemicalCAS1409931-99-2MW331.88FormulaC20H25NO·HCl
CAS number
1409931-99-2
Molecular weight
331.88
Formula
C20H25NO·HCl
InChIKey
COAVTAYHWOYAEJ-UHFFFAOYSA-N
Catalogue number
GB40234
Brand
GLPBIO
Computed properties PubChem CID 71513817 · TPSA 23.5 Ų · H-bond donors 2 · H-bond acceptors 2
TPSA
23.5 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
8
Heavy atoms
23

SMILES C1CC1CN(CCC2=CC=CC=C2)CCC3=CC(=CC=C3)O.Cl

Computed descriptors from PubChem (CID 71513817), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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