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Chemical structure of YUM70

GC62388

YUM70

Also known as N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxyquinolin-7-yl)methyl]butanamide

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1·5 μM for inhibiting GRP78 ATPase activity of the full-length protein· YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer· YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model

ChemicalCAS423145-35-1MW398.84FormulaC21H19ClN2O4
CAS number
423145-35-1
Molecular weight
398.84
Formula
C21H19ClN2O4
Solubility
DMSO ： 100 mg/mL (250·73 mM; Need ultrasonic)
InChIKey
BIQMEYCMAGHOEQ-UHFFFAOYSA-N
Catalogue number
GC62388
Brand
GLPBIO
Computed properties PubChem CID 3138755 · XLogP 4.5 · TPSA 80.7 Ų · H-bond donors 2
XLogP
4.5
TPSA
80.7 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
28

SMILES CCCC(=O)NC(C1=CC2=C(C=C1)OCO2)C3=CC(=C4C=CC=NC4=C3O)Cl

Computed descriptors from PubChem (CID 3138755), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.