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Chemical structure of Taletrectinib

GC62351

Taletrectinib

Also known as 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine;hexanedioic acid

Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor· Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0·207, 0·622, 2·28, and 0·98 nM, respectively· Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants

ChemicalCAS1505515-69-4MW551.61FormulaC29H34FN5O5
CAS number
1505515-69-4
Molecular weight
551.61
Formula
C29H34FN5O5
Solubility
DMSO ： 50 mg/mL (90·64 mM; Need ultrasonic)
InChIKey
DORJQZDOULKINH-QNBGGDODSA-N
Catalogue number
GC62351
Brand
GLPBIO
Computed properties PubChem CID 72694302 · TPSA 152 Ų · H-bond donors 4 · H-bond acceptors 10
TPSA
152 Ų
H-bond donors
4
H-bond acceptors
10
Rotatable bonds
12
Heavy atoms
40

SMILES C[C@H](COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)N[C@H](C)C4=CC(=CC=C4)F)N.C(CCC(=O)O)CC(=O)O

Computed descriptors from PubChem (CID 72694302), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.