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Chemical structure of Talmapimod

GC34072

Talmapimod

Also listed as Talmapimod (SCIO-469)

Talmapimod (SCIO-469) (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM· Talmapimod (SCIO-469) shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs

ChemicalCAS309913-83-5MW513FormulaC27H30ClFN4O3
CAS number
309913-83-5
Molecular weight
513
Formula
C27H30ClFN4O3
Solubility
DMSO ： ≥ 100 mg/mL (194·93 mM)
InChIKey
ZMELOYOKMZBMRB-DLBZAZTESA-N
Catalogue number
GC34072
Brand
GLPBIO
Computed properties PubChem CID 9871074 · XLogP 3.7 · TPSA 65.9 Ų · H-bond donors 0
XLogP
3.7
TPSA
65.9 Ų
H-bond donors
0
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
36

SMILES C[C@@H]1CN([C@H](CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F

Computed descriptors from PubChem (CID 9871074), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.