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Chemical structure of AC-4-130

GC62272

AC-4-130

Also known as 4-[[2-[(4-chlorophenyl)methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(3,5-ditert-butylphenyl)methyl]amino]benzoic acid

AC-4-130 is a potent STAT5 SH2 domain inhibitor· AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription· AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells· AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)

ChemicalCAS1834571-82-2MW751.2FormulaC37H36ClF5N2O5S
CAS number
1834571-82-2
Molecular weight
751.2
Formula
C37H36ClF5N2O5S
InChIKey
NMQUSJQZQWKQBL-UHFFFAOYSA-N
Catalogue number
GC62272
Brand
GLPBIO
Computed properties PubChem CID 154701370 · XLogP 9.1 · TPSA 103 Ų · H-bond donors 1
XLogP
9.1
TPSA
103 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
12
Heavy atoms
51

SMILES CC(C)(C)C1=CC(=CC(=C1)CN(C2=CC=C(C=C2)C(=O)O)C(=O)CN(CC3=CC=C(C=C3)Cl)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F)C(C)(C)C

Computed descriptors from PubChem (CID 154701370), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.