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Chemical structure of Zetomipzomib

GC62239

Zetomipzomib

Also known as (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide

Zetomipzomib (KZR-616), a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome

ChemicalCAS1629677-75-3MW586.68FormulaC30H42N4O8
CAS number
1629677-75-3
Molecular weight
586.68
Formula
C30H42N4O8
InChIKey
GHYOCDFICYLMRF-UTIIJYGPSA-N
Catalogue number
GC62239
Brand
GLPBIO
Computed properties PubChem CID 117607904 · XLogP 0.4 · TPSA 159 Ų · H-bond donors 4
XLogP
0.4
TPSA
159 Ų
H-bond donors
4
H-bond acceptors
9
Rotatable bonds
14
Heavy atoms
42

SMILES C[C@@H](C(=O)N[C@@H]([C@@H](C1=CC=C(C=C1)OC)O)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4

Computed descriptors from PubChem (CID 117607904), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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