Loading...
Chemical structure of PROTAC EED degrader-1

GC62187

PROTAC EED degrader-1

Also known as (2S,4R)-1-[(2S)-2-[[2-[4-[2-[3-[5-[5-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]-6-methyl-2-pyridinyl]propanoylamino]ethoxy]phenoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

PROTAC EED degrader-1 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9·02· PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8·17) targeting the EED subunit

ChemicalCAS2639882-72-5MW1054.2FormulaC55H60FN11O8S
CAS number
2639882-72-5
Molecular weight
1054.2
Formula
C55H60FN11O8S
InChIKey
FSFJUWLIBSALJI-FENRPDQVSA-N
Catalogue number
GC62187
Brand
GLPBIO
Computed properties PubChem CID 145925663 · XLogP 6.7 · TPSA 265 Ų · H-bond donors 5
XLogP
6.7
TPSA
265 Ų
H-bond donors
5
H-bond acceptors
16
Rotatable bonds
21
Heavy atoms
76

SMILES CC1=C(C=CC(=N1)CCC(=O)NCCOC2=CC=C(C=C2)OCC(=O)N[C@H](C(=O)N3C[C@@H](C[C@H]3C(=O)NCC4=CC=C(C=C4)C5=C(N=CS5)C)O)C(C)(C)C)C6=CN=C(N7C6=NN=C7)NCC8=C(C=CC9=C8CCO9)F

Computed descriptors from PubChem (CID 145925663), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.