Loading...
Chemical structure of XY028-140

GC62139

XY028-140

Also known as 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]piperazin-1-yl]-2-oxoethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

XY028-140 is a PROTAC connected by ligands for Cereblon and CDK· XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells

ChemicalCAS2229974-83-6MW760.8FormulaC39H40N10O7
CAS number
2229974-83-6
Molecular weight
760.8
Formula
C39H40N10O7
Solubility
DMSO ： 5·56 mg/mL (7·31 mM; ultrasonic and warming and heat to 60°C)
InChIKey
IWFNIKIERKCKFZ-UHFFFAOYSA-N
Catalogue number
GC62139
Brand
GLPBIO
Computed properties PubChem CID 134605838 · XLogP 2.2 · TPSA 207 Ų · H-bond donors 3
XLogP
2.2
TPSA
207 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
56

SMILES CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C

Computed descriptors from PubChem (CID 134605838), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.