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Chemical structure of MC-SN38

GC62086

MC-SN38

Also known as [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 6-(2,5-dioxopyrrol-1-yl)hexanoate

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC)· SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks

ChemicalCAS1473403-87-0MW585.6FormulaC32H31N3O8
CAS number
1473403-87-0
Molecular weight
585.6
Formula
C32H31N3O8
Solubility
DMSO ： 115 mg/mL (196·38 mM)
InChIKey
ACRMADURFCYBAU-YTTGMZPUSA-N
Catalogue number
GC62086
Brand
GLPBIO
Computed properties PubChem CID 146673122 · XLogP 2.3 · TPSA 143 Ų · H-bond donors 1
XLogP
2.3
TPSA
143 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
10
Heavy atoms
43

SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)OC(=O)CCCCCN5C(=O)C=CC5=O)C2=NC6=C1C=C(C=C6)O

Computed descriptors from PubChem (CID 146673122), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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