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Chemical structure of SK1-I hydrochloride

GC62027

SK1-I hydrochloride

Also known as (E,2R,3S)-2-(methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diol;hydrochloride

SK1-I hydrochloride (BML-258 hydrochloride), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM· SK1-I hydrochloride shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β· SK1-I hydrochloride enhances autophagy and has antitumor activity

ChemicalCAS2366222-05-9MW313.86FormulaC17H28ClNO2
CAS number
2366222-05-9
Molecular weight
313.86
Formula
C17H28ClNO2
Solubility
DMSO ： 250 mg/mL (796·53 mM)
InChIKey
SGCJOKUPGVFNKS-UUCPMUBFSA-N
Catalogue number
GC62027
Brand
GLPBIO
Computed properties PubChem CID 49793059 · TPSA 52.5 Ų · H-bond donors 4 · H-bond acceptors 3
TPSA
52.5 Ų
H-bond donors
4
H-bond acceptors
3
Rotatable bonds
9
Heavy atoms
21

SMILES CCCCCC1=CC=C(C=C1)/C=C/[C@@H]([C@@H](CO)NC)O.Cl

Computed descriptors from PubChem (CID 49793059), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.