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Chemical structure of SK1-I

GC61597

SK1-I

Also known as (E,2R,3S)-2-(methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diol

SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 ?M· SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β· SK1-I enhances autophagy and has antitumor activity

ChemicalCAS1072443-89-0MW277.4FormulaC17H27NO2
CAS number
1072443-89-0
Molecular weight
277.4
Formula
C17H27NO2
InChIKey
JYEXUQKROPHSEF-SFDDJJRUSA-N
Catalogue number
GC61597
Brand
GLPBIO
Computed properties PubChem CID 44815217 · XLogP 3.1 · TPSA 52.5 Ų · H-bond donors 3
XLogP
3.1
TPSA
52.5 Ų
H-bond donors
3
H-bond acceptors
3
Rotatable bonds
9
Heavy atoms
20

SMILES CCCCCC1=CC=C(C=C1)/C=C/[C@@H]([C@@H](CO)NC)O

Computed descriptors from PubChem (CID 44815217), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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