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Chemical structure of PR-924

GC61945

PR-924

Also known as N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide

PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM· PR-924 covalently modifies proteasomal N-terminal threonine active sites· PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells· PR-924 has antitumor activities

ChemicalCAS1416709-79-9MW618.72FormulaC37H38N4O5
CAS number
1416709-79-9
Molecular weight
618.72
Formula
C37H38N4O5
InChIKey
ADBUEVSHEJICCM-LZNHGOJSSA-N
Catalogue number
GC61945
Brand
GLPBIO
Computed properties PubChem CID 92135659 · XLogP 4.5 · TPSA 133 Ų · H-bond donors 4
XLogP
4.5
TPSA
133 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
12
Heavy atoms
46

SMILES CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)[C@]6(CO6)C

Computed descriptors from PubChem (CID 92135659), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.