Loading...
Chemical structure of KMH-233

GC61845

KMH-233

Also known as (2S)-2-amino-3-[3-[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]carbamoyl]phenyl]propanoic acid

KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth· KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM)

ChemicalCAS1941174-13-5MW587.58FormulaC32H25N7O5
CAS number
1941174-13-5
Molecular weight
587.58
Formula
C32H25N7O5
Solubility
DMSO ： 100 mg/mL (170·19 mM)
InChIKey
MLNOOVGSMCJSCE-DEOSSOPVSA-N
Catalogue number
GC61845
Brand
GLPBIO
Computed properties PubChem CID 154730690 · XLogP 2 · TPSA 196 Ų · H-bond donors 4
XLogP
2
TPSA
196 Ų
H-bond donors
4
H-bond acceptors
9
Rotatable bonds
9
Heavy atoms
44

SMILES CNC(=O)COC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)NC(=O)C5=CC=CC(=C5)C[C@@H](C(=O)O)N)C#N

Computed descriptors from PubChem (CID 154730690), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.