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Chemical structure of Thalidomide-O-amido-C3-COOH

GC61329

Thalidomide-O-amido-C3-COOH

Also known as 4-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]butanoic acid

Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology

ChemicalCAS2308035-51-8MW417.37FormulaC19H19N3O8
CAS number
2308035-51-8
Molecular weight
417.37
Formula
C19H19N3O8
Solubility
DMSO: ≥ 55·5 mg/mL (132·98 mM)
InChIKey
RZVLFEVSXBBCIP-UHFFFAOYSA-N
Catalogue number
GC61329
Brand
GLPBIO
Computed properties PubChem CID 131704499 · XLogP -0.7 · TPSA 159 Ų · H-bond donors 3
XLogP
-0.7
TPSA
159 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
30

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCC(=O)O

Computed descriptors from PubChem (CID 131704499), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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