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Chemical structure of SP-96

GC61287

SP-96

Also known as 1-(3-fluorophenyl)-3-[3-[[7-(1-methylpyrazol-4-yl)quinazolin-4-yl]amino]phenyl]urea

SP-96 is a?highly potent, selective and non-ATP-competitive Aurora B (IC50=0·316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT· SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM)· SP-96 can be used for the research of triple negative breast cancer (TNBC)

ChemicalCAS2682114-54-9MW453.47FormulaC25H20FN7O
CAS number
2682114-54-9
Molecular weight
453.47
Formula
C25H20FN7O
InChIKey
CGDYRZUPKPBLND-UHFFFAOYSA-N
Catalogue number
GC61287
Brand
GLPBIO
Computed properties PubChem CID 154573766 · XLogP 4 · TPSA 96.8 Ų · H-bond donors 3
XLogP
4
TPSA
96.8 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
34

SMILES CN1C=C(C=N1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC(=CC=C4)NC(=O)NC5=CC(=CC=C5)F

Computed descriptors from PubChem (CID 154573766), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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