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Chemical structure of SJF620

GC61280

SJF620

Also known as 3-[6-[2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7·9 nM· SJF620 contains a Lenalidomide analog for recruiting CRBN

ChemicalCAS2376187-16-3MW760.84FormulaC41H44N8O7
CAS number
2376187-16-3
Molecular weight
760.84
Formula
C41H44N8O7
Solubility
DMSO： 100 mg/mL (131·43 mM)
InChIKey
UJJYPBWMGIPXOE-UHFFFAOYSA-N
Catalogue number
GC61280
Brand
GLPBIO
Computed properties PubChem CID 139466026 · XLogP 3.2 · TPSA 176 Ų · H-bond donors 2
XLogP
3.2
TPSA
176 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
15
Heavy atoms
56

SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)OCCOCCOCCN4CCC(CC4)N5C6=NC=NC(=C6C(=N5)C7=CC=C(C=C7)OC8=CC=CC=C8)N

Computed descriptors from PubChem (CID 139466026), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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