GC61270
SD-36
SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members· SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM)· SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models· SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase
ChemicalCAS2429877-44-9MW1158.15FormulaC59H62F2N9O12P
- CAS number
- 2429877-44-9
- Molecular weight
- 1158.15
- Formula
- C59H62F2N9O12P
- Solubility
- DMSO： 150 mg/mL (129·52 mM)
- Catalogue number
- GC61270
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il