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Chemical structure of AZ12672857

GC60611

AZ12672857

Also known as 2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamine

AZ12672857 is an orally active inhibitor of EphB4 (IC50=1·3 nM) and Src kinases· AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)

ChemicalCAS945396-55-4MW486.57FormulaC26H30N8O2
CAS number
945396-55-4
Molecular weight
486.57
Formula
C26H30N8O2
Solubility
DMSO： 25 mg/mL (51·38 mM)
InChIKey
QLFGDTPACJHLRY-UHFFFAOYSA-N
Catalogue number
GC60611
Brand
GLPBIO
Computed properties PubChem CID 49831162 · XLogP 3.2 · TPSA 94.7 Ų · H-bond donors 2
XLogP
3.2
TPSA
94.7 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
36

SMILES CN(C1=NC(=NC=C1)NC2=CC(=CC(=C2)N3CCOCC3)N4CCOCC4)C5=CC=CC6=C5C=NN6

Computed descriptors from PubChem (CID 49831162), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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