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Chemical structure of ABT-100

GC60548

ABT-100

Also known as 4-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(3-methylimidazol-4-yl)ethoxy]-3-[4-(trifluoromethoxy)phenyl]benzonitrile

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor· ABT-100 inhibits cell proliferation (IC50s of 2·2 nM, 3·8 nM, 5·9 nM, 6·9 nM, 9·2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis· ABT-100 possesses broad-spectrum antitumor activity

ChemicalCAS450839-40-4MW504.46FormulaC27H19F3N4O3
CAS number
450839-40-4
Molecular weight
504.46
Formula
C27H19F3N4O3
InChIKey
HEUVRFNVTLGKMZ-SANMLTNESA-N
Catalogue number
GC60548
Brand
GLPBIO
Computed properties PubChem CID 6451154 · XLogP 4.6 · TPSA 104 Ų · H-bond donors 1
XLogP
4.6
TPSA
104 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
37

SMILES CN1C=NC=C1[C@](COC2=C(C=C(C=C2)C#N)C3=CC=C(C=C3)OC(F)(F)F)(C4=CC=C(C=C4)C#N)O

Computed descriptors from PubChem (CID 6451154), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.