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Chemical structure of UC2288

GC60376

UC2288

Also known as 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]urea

UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib· UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability· UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM

ChemicalCAS1394011-91-6MW481.82FormulaC20H18ClF6N3O2
CAS number
1394011-91-6
Molecular weight
481.82
Formula
C20H18ClF6N3O2
InChIKey
ISPSOOYSNVVMMB-UHFFFAOYSA-N
Catalogue number
GC60376
Brand
GLPBIO
Computed properties PubChem CID 60196635 · XLogP 5.6 · TPSA 63.3 Ų · H-bond donors 2
XLogP
5.6
TPSA
63.3 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
4
Heavy atoms
32

SMILES C1CC(CCC1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=NC=C(C=C3)C(F)(F)F

Computed descriptors from PubChem (CID 60196635), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.