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Chemical structure of Thalidomide-5-OH

GC60361

Thalidomide-5-OH

Also known as 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein· Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs

ChemicalCAS64567-60-8MW274.23FormulaC13H10N2O5
CAS number
64567-60-8
Molecular weight
274.23
Formula
C13H10N2O5
Solubility
DMSO: 62·5 mg/mL (227·91 mM)
InChIKey
LJBQRRQTZUJWRC-UHFFFAOYSA-N
Catalogue number
GC60361
Brand
GLPBIO
Computed properties PubChem CID 5743568 · XLogP 0 · TPSA 104 Ų · H-bond donors 2
XLogP
0
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
1
Heavy atoms
20

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)O

Computed descriptors from PubChem (CID 5743568), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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