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Chemical structure of AZD-8529 mesylate

GC60065

AZD-8529 mesylate

Also known as methanesulfonic acid;7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes

ChemicalCAS1314217-69-0MW583.58FormulaC25H28F3N5O6S
CAS number
1314217-69-0
Molecular weight
583.58
Formula
C25H28F3N5O6S
Solubility
DMSO： 41·67 mg/mL (71·40 mM)
InChIKey
HRHCPVNKPOTCGB-UHFFFAOYSA-N
Catalogue number
GC60065
Brand
GLPBIO
Computed properties PubChem CID 53495155 · TPSA 146 Ų · H-bond donors 2 · H-bond acceptors 13
TPSA
146 Ų
H-bond donors
2
H-bond acceptors
13
Rotatable bonds
6
Heavy atoms
40

SMILES CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O

Computed descriptors from PubChem (CID 53495155), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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