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Chemical structure of AZD-9291 mesylate

GC16698

AZD-9291 mesylate

Also known as N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid

AZD-9291 mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M· Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

ChemicalCAS1421373-66-1MW595.71FormulaC29H37N7O5S
CAS number
1421373-66-1
Molecular weight
595.71
Formula
C29H37N7O5S
Solubility
17mg/mL in DMSO (ultrasonic and warming and heat to 50°C)
InChIKey
FUKSNUHSJBTCFJ-UHFFFAOYSA-N
Catalogue number
GC16698
Brand
GLPBIO
Computed properties PubChem CID 78357807 · TPSA 150 Ų · H-bond donors 3 · H-bond acceptors 10
TPSA
150 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
10
Heavy atoms
42

SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O

Computed descriptors from PubChem (CID 78357807), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.