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Chemical structure of PPM-3

GC59490

PPM-3

Also known as (2S,4R)-1-[(2S)-2-[7-[4-[4-[(5,11-dimethyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]heptanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

Potent and selective ERK5 Degrader (PROTAC®)

ChemicalCAS3032388-42-1MW1000.28FormulaC54H69N11O6S
CAS number
3032388-42-1
Molecular weight
1000.28
Formula
C54H69N11O6S
Solubility
DMSO： 100·03mg/mL
InChIKey
QGJQNPNZAYRDMS-OESUUHGFSA-N
Catalogue number
GC59490
Brand
GLPBIO
Computed properties PubChem CID 168679766 · XLogP 7.1 · TPSA 217 Ų · H-bond donors 4
XLogP
7.1
TPSA
217 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
18
Heavy atoms
72

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCN4CCN(CC4)C5=CC(=C(C=C5)NC6=NC=C7C(=N6)N(C8=CC=CC=C8C(=O)N7C)C)OC)O

Computed descriptors from PubChem (CID 168679766), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.