Loading...
Chemical structure of MS 143

GC59482

MS 143

Also known as 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-[4-[12-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-12-oxododecanoyl]piperazin-1-yl]propyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

AKT kinase Degrader (PROTAC®)

ChemicalCAS2376137-41-4MW1121.89FormulaC59H81ClN12O6S
CAS number
2376137-41-4
Molecular weight
1121.89
Formula
C59H81ClN12O6S
Solubility
DMSO： 112·19mg/mL
InChIKey
DESJGFOSPPNXOH-XUXNHVGISA-N
Catalogue number
GC59482
Brand
GLPBIO
Computed properties PubChem CID 155410582 · XLogP 7.6 · TPSA 263 Ų · H-bond donors 6
XLogP
7.6
TPSA
263 Ų
H-bond donors
6
H-bond acceptors
13
Rotatable bonds
25
Heavy atoms
79

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCC(=O)N4CCN(CC4)CC[C@@H](C5=CC=C(C=C5)Cl)NC(=O)C6(CCN(CC6)C7=NC=NC8=C7C=CN8)N)O

Computed descriptors from PubChem (CID 155410582), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.