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Chemical structure of MRX-2843 (UNC2371)

GC32769

MRX-2843 (UNC2371)

Also known as 4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol

MRX-2843 (UNC2371) (UNC2371) is an orally active, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1·3 nM for MERTK and 0·64 nM for FLT3, respectively

ChemicalCAS1429882-07-4MW488.67FormulaC29H40N6O
CAS number
1429882-07-4
Molecular weight
488.67
Formula
C29H40N6O
Solubility
DMSO ： 31·25 mg/mL (63·95 mM)
InChIKey
LBEJYFVJIPQSNX-UHFFFAOYSA-N
Catalogue number
GC32769
Brand
GLPBIO
Computed properties PubChem CID 89495685 · XLogP 4.2 · TPSA 69.5 Ų · H-bond donors 2
XLogP
4.2
TPSA
69.5 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
36

SMILES CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN(C4=NC(=NC=C34)NCCC5CC5)C6CCC(CC6)O

Computed descriptors from PubChem (CID 89495685), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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