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Chemical structure of ABT-263-d8

GC49745

ABT-263-d8

Also known as 4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide

ABT-263-d8 is the deuterium labeled Navitoclax· Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM

ChemicalCAS1217620-38-6MW982.7FormulaC47H47ClD8F3N5O6S3
CAS number
1217620-38-6
Molecular weight
982.7
Formula
C47H47ClD8F3N5O6S3
Solubility
DMF： 30mg/mL,DMF：PBS (pH 7·2) (1：2)： ·3mg/mL,DMSO： 25mg/mL,Ethanol： ·5mg/mL
InChIKey
JLYAXFNOILIKPP-YSUYZUONSA-N
Catalogue number
GC49745
Brand
GLPBIO
Computed properties PubChem CID 46779840 · XLogP 9.6 · TPSA 170 Ų · H-bond donors 2
XLogP
9.6
TPSA
170 Ų
H-bond donors
2
H-bond acceptors
14
Rotatable bonds
16
Heavy atoms
65

SMILES [2H]C1(C(OC(C(N1CC[C@H](CSC2=CC=CC=C2)NC3=C(C=C(C=C3)S(=O)(=O)NC(=O)C4=CC=C(C=C4)N5CCN(CC5)CC6=C(CCC(C6)(C)C)C7=CC=C(C=C7)Cl)S(=O)(=O)C(F)(F)F)([2H])[2H])([2H])[2H])([2H])[2H])[2H]

Computed descriptors from PubChem (CID 46779840), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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