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Chemical structure of Tpl2 Kinase Inhibitor

GC45067

Tpl2 Kinase Inhibitor

Also known as 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile

Tpl2 Kinase Inhibitor (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers

ChemicalCAS871307-18-5MW404.8FormulaC21H14ClFN6
CAS number
871307-18-5
Molecular weight
404.8
Formula
C21H14ClFN6
Solubility
DMF： 1 mg/ml,DMF：PBS(pH7·2) (1：2)： 0·33 mg/ml,DMSO： 1 mg/ml
InChIKey
NMEUKWOOQOHUNA-UHFFFAOYSA-N
Catalogue number
GC45067
Brand
GLPBIO
Computed properties PubChem CID 9549300 · XLogP 4.4 · TPSA 86.5 Ų · H-bond donors 2
XLogP
4.4
TPSA
86.5 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
29

SMILES C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl

Computed descriptors from PubChem (CID 9549300), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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