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Chemical structure of Suc-Leu-Tyr-AMC

GC44963

Suc-Leu-Tyr-AMC

Also known as 4-[[(2S)-1-[[3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

Suc-Leu-Tyr-AMC, a fluorescent substrate for calpain I and II and papain (cysteine protease) measuring the chymotrypsin-like peptidase activity of the 20S proteasome, emits bright fluorescence has been used extensively for calpain I and II and papain evaluation (Ex/Em: 360/460nm)

ChemicalCAS94367-20-1MW551.6FormulaC29H33N3O8
CAS number
94367-20-1
Molecular weight
551.6
Formula
C29H33N3O8
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,DMSO：PBS(pH7·2) (1：1)： 0·5 mg/ml,Ethanol： 20 mg/ml
InChIKey
VSWNAJAOJZXWBM-FTJGSZSVSA-N
Catalogue number
GC44963
Brand
GLPBIO
Computed properties PubChem CID 125141 · XLogP 2.5 · TPSA 171 Ų · H-bond donors 5
XLogP
2.5
TPSA
171 Ų
H-bond donors
5
H-bond acceptors
8
Rotatable bonds
12
Heavy atoms
40

SMILES CCC(C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C)NC(=O)CCC(=O)O

Computed descriptors from PubChem (CID 125141), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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