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Chemical structure of Suc-Leu-Leu-Val-Tyr-AMC

GC44962

Suc-Leu-Leu-Val-Tyr-AMC

Also known as 4-[[1-[[1-[[(2S)-1-[[(2S)-3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

Suc-Leu-Leu-Val-Tyr-AMC is a tetrapeptide compound that serves as a fluorogenic substrate for the 20S proteasome , chymotrypsin-like proteases , and calpains , with maximum excitation and emission wavelengths of 345 nm and 445 nm, respectively

ChemicalCAS94367-21-2MW763.9FormulaC40H53N5O10
CAS number
94367-21-2
Molecular weight
763.9
Formula
C40H53N5O10
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,DMSO：PBS(pH7·2) (1：1)： 0·5 mg/ml,Ethanol： 20 mg/ml
InChIKey
UVFAEQZFLBGVRM-BIMKKRMNSA-N
Catalogue number
GC44962
Brand
GLPBIO
Computed properties PubChem CID 121886 · XLogP 4.3 · TPSA 229 Ų · H-bond donors 7
XLogP
4.3
TPSA
229 Ų
H-bond donors
7
H-bond acceptors
10
Rotatable bonds
19
Heavy atoms
55

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CCC(=O)O

Computed descriptors from PubChem (CID 121886), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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