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Chemical structure of PD 089828

GC44583

PD 089828

Also known as 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0·15, 1·76, and 5·47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0·18 μM)

ChemicalCAS179343-17-0MW405.3FormulaC18H18Cl2N6O
CAS number
179343-17-0
Molecular weight
405.3
Formula
C18H18Cl2N6O
Solubility
DMSO： 25 mg/ml,Ethanol： 1 mg/ml
InChIKey
RRWSNCZYJCOEFX-UHFFFAOYSA-N
Catalogue number
GC44583
Brand
GLPBIO
Computed properties PubChem CID 5328112 · XLogP 3.7 · TPSA 106 Ų · H-bond donors 3
XLogP
3.7
TPSA
106 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
27

SMILES CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl

Computed descriptors from PubChem (CID 5328112), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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