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Chemical structure of NVP-BEZ235 (hydrochloride)

GC44475

NVP-BEZ235 (hydrochloride)

Also known as 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile;hydrochloride

NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies

ChemicalCAS2319647-83-9MW506FormulaC30H23N5O•HCl
CAS number
2319647-83-9
Molecular weight
506
Formula
C30H23N5O•HCl
Solubility
DMF： 0·5 mg/ml,DMSO： 1 mg/ml,Ethanol： 0·5 mg/ml
InChIKey
VDZVGMJFBACERH-UHFFFAOYSA-N
Catalogue number
GC44475
Brand
GLPBIO
Computed properties PubChem CID 132285234 · TPSA 73.1 Ų · H-bond donors 1 · H-bond acceptors 4
TPSA
73.1 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
37

SMILES CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5.Cl

Computed descriptors from PubChem (CID 132285234), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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