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Chemical structure of NVP-2

GC34056

NVP-2

Also known as 4-[[[6-[5-chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-4-pyridinyl]-2-pyridinyl]amino]methyl]oxane-4-carbonitrile

NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0·514 nM· NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0·584 ?M, 0·706 ?M, and 0·605 ?M, respectively· NVP-2 induces cell apoptosis

ChemicalCAS1263373-43-8MW513.07FormulaC27H37ClN6O2
CAS number
1263373-43-8
Molecular weight
513.07
Formula
C27H37ClN6O2
Solubility
DMSO ： ≥ 100 mg/mL (194·91 mM)
InChIKey
XWQVQSXLXAXOPJ-QNGMFEMESA-N
Catalogue number
GC34056
Brand
GLPBIO
Computed properties PubChem CID 66937006 · XLogP 4.3 · TPSA 104 Ų · H-bond donors 3
XLogP
4.3
TPSA
104 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
10
Heavy atoms
36

SMILES C[C@H](COC)NC1CCC(CC1)NC2=NC=C(C(=C2)C3=NC(=CC=C3)NCC4(CCOCC4)C#N)Cl

Computed descriptors from PubChem (CID 66937006), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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