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Chemical structure of NIAD-4

GC44399

NIAD-4

Also known as 2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile

NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM)

ChemicalCAS868592-56-7MW334.4FormulaC18H10N2OS2
CAS number
868592-56-7
Molecular weight
334.4
Formula
C18H10N2OS2
Solubility
DMF： 25 mg/mL,DMSO： 25 mg/mL,DMSO：PBS(pH 7·2) (1：2)： 0·3 mg/mL,Ethanol： 0·2 mg/mL
InChIKey
KLFRZDOQQDHVSS-UHFFFAOYSA-N
Catalogue number
GC44399
Brand
GLPBIO
Computed properties PubChem CID 9639427 · XLogP 4.4 · TPSA 124 Ų · H-bond donors 1
XLogP
4.4
TPSA
124 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
23

SMILES C1=CC(=CC=C1C2=CC=C(S2)C3=CC=C(S3)C=C(C#N)C#N)O

Computed descriptors from PubChem (CID 9639427), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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