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Chemical structure of JNJ-47965567

GC43931

JNJ-47965567

Also known as N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide

JNJ-47965567 is a centrally permeable, high affinity, selective P2X7 antagonist with IC50 values of 5nM and 10nM for human and mouse P2X7 receptors, respectively

ChemicalCAS1428327-31-4MW488.6FormulaC28H32N4O2S
CAS number
1428327-31-4
Molecular weight
488.6
Formula
C28H32N4O2S
Solubility
DMF： 30 mg/mL,DMSO： 30 mg/mL,DMSO：PBS(pH 7·2) (1：3)： 0·25 mg/mL,Ethanol： 12·5 mg/mL
InChIKey
XREFXUCWSYMIOG-UHFFFAOYSA-N
Catalogue number
GC43931
Brand
GLPBIO
Computed properties PubChem CID 66553218 · XLogP 4.4 · TPSA 83 Ų · H-bond donors 1
XLogP
4.4
TPSA
83 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
35

SMILES C1COCCC1(CNC(=O)C2=C(N=CC=C2)SC3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5

Computed descriptors from PubChem (CID 66553218), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.