Loading...
Chemical structure of AFN-1252

GC40646

AFN-1252

Also known as (E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide

AFN-1252 is an inhibitor of staphylococcal enoyl-acyl carrier protein reductase (FabI; Ki = 12·8 nM), an enzyme that activates bacterial fatty acid biosynthesis

ChemicalCAS620175-39-5MW375.4FormulaC22H21N3O3
CAS number
620175-39-5
Molecular weight
375.4
Formula
C22H21N3O3
Solubility
DMSO ： 5·8 mg/mL (15·45 mM; Need ultrasonic)
InChIKey
QXTWSUQCXCWEHF-JXMROGBWSA-N
Catalogue number
GC40646
Brand
GLPBIO
Computed properties PubChem CID 10407120 · XLogP 2.5 · TPSA 75.4 Ų · H-bond donors 1
XLogP
2.5
TPSA
75.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
28

SMILES CC1=C(OC2=CC=CC=C12)CN(C)C(=O)/C=C/C3=CC4=C(NC(=O)CC4)N=C3

Computed descriptors from PubChem (CID 10407120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.