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Chemical structure of CR-1-31-B

GC39744

CR-1-31-B

Also known as (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide

CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor· CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis· CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA· CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells

ChemicalCAS1352914-52-3MW507.53FormulaC28H29NO8
CAS number
1352914-52-3
Molecular weight
507.53
Formula
C28H29NO8
Solubility
DMSO： 300 mg/mL (591·10 mM)
InChIKey
KLSIFOJPWJBRFH-GWNOIRNCSA-N
Catalogue number
GC39744
Brand
GLPBIO
Computed properties PubChem CID 56946209 · XLogP 2.7 · TPSA 116 Ų · H-bond donors 3
XLogP
2.7
TPSA
116 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
37

SMILES COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)NOC)C5=CC=CC=C5

Computed descriptors from PubChem (CID 56946209), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.