Loading...
Chemical structure of CS1

GB40161

CS1

Also known as 4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol

TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4·3 µM, 11·5 µM, and 4·6 µM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively)· CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6-10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide

ChemicalCAS1448009-94-6MW252.26FormulaC16H12O3
CAS number
1448009-94-6
Molecular weight
252.26
Formula
C16H12O3
InChIKey
LDFFDYWHCCDSBO-UHFFFAOYSA-N
Catalogue number
GB40161
Brand
GLPBIO
Computed properties PubChem CID 57173257 · XLogP 3.7 · TPSA 60.7 Ų · H-bond donors 3
XLogP
3.7
TPSA
60.7 Ų
H-bond donors
3
H-bond acceptors
3
Rotatable bonds
1
Heavy atoms
19

SMILES C1=CC2=C(C=CC(=C2)O)C=C1C3=CC(=C(C=C3)O)O

Computed descriptors from PubChem (CID 57173257), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.